Baron Cromwell, Knight of Bath, Knight of the Shire for Kent.

Only son and heir to Thomas Cromwell, Lord Cromwell, Earl of Essex and Elizabeth Wykes. Brother of Anne and Grace. Grandson of Walter Cromwell and Katherine Glossop, and Henry Wykes.

Husband of Lady Elizabeth Seymour, daughter of Sir John Seymour and Margaret Wentworth, sister of Jane Seymour and widow of Sir Anthony Ughtred who died 20 Dec 1534. They were married in 1537, and had five children:
Henry Cromwell, 2nd Baron Cromwell
Edward, died young
Catherine, wife of Sir John Strode
Frances, wife of Richard Strode
Thomas, married Katherine Gardner

Gregory lost his mother at an early age in 1528 to the 'sweating sickness', and it is thought his two sisters followed shortly after. His father was devoted to his son, and his sister's older son, Richard, the three became a close knit family. Gregory grew to share in his father's religious beliefs, as did Richard, who took his uncle's name when he became Privy Councillor in 1531.

Gregory was firstly cared for by a nun, Margaret Vernon, and tutored by teachers of his father's choosing, then attended Cambridge, taught by a carefully select and extensive list of scholars.

Lady Elizabeth Ughtred, recently widowed and living poorly in York, had written Gregory's father inquiring about procuring one of the dissolved monasteries. Considered a perfect match, she and Gregory wed between July 17th and August 3rd at the Seymour home Wulfhall, Wiltshire.

Gregory and Elizabeth took part in the funeral procession of Queen Jane Seymour, Richard Cromwell carried the banners. They moved to the Cluniac Priory of St Pancras, Lewes in 1538 after the Priory was granted to his father, and the monastery demolished immediately, leaving the Priory to become the new residence for Gregory and Elizabeth. The Plague broke out, Gregory and Elizabeth fled to another of his father's houses, "The Motte", then to Leeds Castle where Thomas was appointed Constable in 1539.

Gregory was summoned to Parliament April 1539, and traveled to Calais to welcome Anne of Cleves, Elizabeth was assigned to Anne's household in January 1540, Thomas created Earl of Essex and Gregory assumed the title of Baron in April, and the May Day jousts included Gregory, Richard, Sir John Dudley, Sir Thomas Seymour and fourty-six defendants, and Richard was knighted.

The Bishop of Winchester, Stephen Gardiner, was finally successful in destroying his enemy, Gregory's father, who was executed at Tower Hill July 28th. Gregory and Elizabeth found themselves homeless and penniless. Finally, In December, King Henry grew to regret the execution and must have looked kindly upon the couple as Gregory was called to Parliament, was given Oakham Castle, made a peer of the realm, and created Baron Cromwell, a new title opposed to the restoration of his father's title.

The following February would bring the restoration of some of his father's lands, including Launde and Lodngton, lands actually purchased by his father. He also owned the Manors of Clapthorne, Piddington and Hackleton in Northamptonshire as well as the manors of Northelmeham and Beteley in Norfolk.

Gregory died suddenly at his home in Launde Abbey of the sweating sickness, the cause of this disease is still unknown. He was buried in a magnificent tomb in the chapel.
He would be succeeded by his son, Henry, and his last son was born posthumously in early 1552. Elizabeth would marry a third time to John Paulet, Lord St. John, and was buried at Basing, Hampshire.