Margaret is a daughter of Baltis or Baltus Moak from Sharon, New York and Nancy Winney from Cherry Valley, New York. She was named after her paternal grandmother, Margaret Fenner Moak. She was born in either White Pigeon, Michigan or in LaGrange County, Indiana, at or near the home of her Uncle Peter Moak.

1850 Victoria Twp, Knox CO census
Bartus MOAK,29,M,Farmer,b.unk (New York)
Nancy MOAK,28,F,b.NY
Margaret MOAK,7,F,b.IA (Indiana)
Daniel WINNEY,15,M,Laborer,b.NY (or Michigan)
John MOAK,22,Laborer,b.NY

1860 CENSUS, Township 14 N 2 W, Mercer County, IL
Page 803, DWELLING # 1078, HH # 1078
James Denniston, age 22, Male, Laborer, B: Penn.
Nancy " , age 34, Female, B: NY
Margaret Moak, age 16, Female, Domestic, B: Michigan

Margaret Moak was the 2nd wife of Isaac N Ailes, married January 12, 1863 in Viola, Mercer County, Illinois.

Mercer CO IL marriage records
AILES, ISAAC N MOAK, MARGARET E 01/12/1863 00A/0084 00001688 MERCER COUNTY

Isaac appears to have remarried Mary Elizabeth Burrows, born in PA before 1870.
At issue is the 1944 death record for Grover Cleveland Ailes, born 25 Sep 1884, Malian, Rock Island County, Illinois lists his parents as Isaac Newton Ailes and Mary Elizabeth Burrows.
Margaret died before 3 September 1864 when Isaac married Mary Elizabeth Burrows. Margaret and Isaac evidently didn't have any children. He had 6 by his first wife Jane Henderson and seven by his third wife Mary Elizabeth. Isaac appears to have remarried Mary Elizabeth Burrows, born in PA before 1870.
At issue is the 1944 death record for Grover Cleveland Ailes, born 25 Sep 1884, Malian, Rock Island County, Illinois lists his parents as Isaac Newton Ailes and Mary Elizabeth Burrows.

1870 IL Mercer Greene
Ailes, Isaac 47 PA
Mary E. 27 PA
Nancy 5 IL
Sarah A. 3 IL
James 1 IL

1880 IL Rock Island Milan
Ailes, Isaac 56 PA PA PA
Mary E. 36 PA PA PA
Sarah 12 IL
James 11 IL
Nettie M. 5 IL
Robert B. 3/12 IL

1900 IL Rock Island Black Hawk
Ailes, Isaac Oct 1823 widow OH OH OH
Nettie M. may 1875 IL OH PA
Robert feb 1880
Susan Jan 1883
Cleare (son) sep 1884

Nancy Winney Moak Dennison states that both of her children by first husband (Baltis Moak) are dead in her 1903 pension deposition for James S Dennison.
Children of Margaret Elizabeth Moak and Isaac Newton Ailes might be the following, all born in Mercer County, Illinois.
i. NANCY AILES, b. Abt. 1865.
ii. SARAH, b. 1868.
iii. JAMES, b. 1869.