Emperor of Byzantium 1185 to 1195, and again from 1203 to 1204. A great-grandson of Emperor Alexios I, he participated in a rebellion against the usurper emperor, Andronikos I, but was pardoned. When a prophecy foretold that Andronikos' successor would be named 'Isaakios', the emperor's crony Stephanos Hagiochristophorites set out to arrest Isaakios Angelos.
When he confronted Isaakios, Hagiochristophorites was killed by a blow to the skull. Isaakios then sought refuge in the Hagia Sophia, where the populace proclaimed him emperor. Andronikos I tried to flee the city, but was captured, tortured, and killed. Now emperor, Isaakios II became known for his decadence and effeminacy. He was deposed and blinded by his own beloved brother, Alexios III Angelos, in 1195.
Isaakios' son, Alexios IV, fled to Germany where his sister Irene Angela of Byzantium was empress. He returned to Constantinople with the Fourth Crusade in 1204. Alexios III was deposed, and Isaakios II was restored as emperor. He quarreled with his son, but when Alexios IV was murdered by the courtier Mourtzouphlos (afterwards Alexios V), Isaakios II died immediately afterward of shock and grief.