Darwin Andrus was born in Rutland, Vermont and married Elizabeth Naomey Andrus (perhaps a cousin) in May 1830 in Tioga, Pennsylvania. Together they had at least six children: Jerome, Huldah Lucretia, Mary Lovina, Orasmus Merritt, John Elisha, and Sarah Maria Anna. Elizabeth died in Bradford County, Pennsylvania in about 1852. Darwin moved west to Wisconsin and settled in Nebraska (by 1876 Nebraska state census). He remarried to Maria Hannah (Cromack) McGonegal in February 1879.