Her parents are William Strain and Mary Kimball. Melissa was the first wife of Benjamin Blake Anderson. They had 2 children:
1. Estelle Marie Anderson
2. Pearl Anderson
1880 census: Shows M. Strain living at 7th Ward, Columbus, Franklin, Ohio with her mother, Mary, and brothers Ellsworth, James, Ker. and sister Jenny.
Also lists her as a clerk.
She died from Consumption and her husband married two more times.