An early leader of charitable work, she also founded the first nursing school in the United States. During the Civil War, at the of 24, she was appointed as the corresponding secretary in the Woman's Central Association of Relief (WCAR) in New York City, which coordinated the efforts of the volunteers on the home front, including distribution of millions of dollars of supplies, and providing training materials.

In 1873 she organized the New York State Charities Aid Association and in the following year established the first training school for nurses in the United States in connection with Bellevue Hospital. She also worked on projects to address tuberculosis and blindness. In 1907 she was appointed one of the original trustees of the Russell Sage Foundation, founded by Margaret Olivia Slocum Sage.

Schuyler was a descendant of General Philip Schuyler and Founding Father Alexander Hamilton

An early leader of charitable work, she also founded the first nursing school in the United States. During the Civil War, at the of 24, she was appointed as the corresponding secretary in the Woman's Central Association of Relief (WCAR) in New York City, which coordinated the efforts of the volunteers on the home front, including distribution of millions of dollars of supplies, and providing training materials.

In 1873 she organized the New York State Charities Aid Association and in the following year established the first training school for nurses in the United States in connection with Bellevue Hospital. She also worked on projects to address tuberculosis and blindness. In 1907 she was appointed one of the original trustees of the Russell Sage Foundation, founded by Margaret Olivia Slocum Sage.

Schuyler was a descendant of General Philip Schuyler and Founding Father Alexander Hamilton