He was the proprietor of the Jefferds Tavern in Wells,ME. This tavern was moved to Old York Village in York,ME, where it stands today as a museum.
He married, first, on Jul 8,1752 at Wells,ME, Hannah Hill.
He married, second, on Dec 2,1779 at Dover,NH, Mrs. Lois (----) Storer.
Children(by first marriage): William Jefferds, Elizabeth Jefferds Wells, Hannah Jefferds Fiske, Samuel Jefferds Jr, Sarah Clark Jefferds Emery, Nathaniel Jefferds, and Bartholomew Jefferds.