Samuel was the son of Joseph Hills Sr. & Hannah Smith. He married Abigail Wheeler on May 20, 1679 in West Newbury, Essex County, Massachusetts. To this union, 13 children were born:
Samuel was a sergeant in the Indian War with King Philip. He was listed as one of the survivors of Captain Thomas Lathrop's Company in the disastrous battle of Muddy Brook, now called Bloody Brook, 18 September 1675. Samuel was also at the Battle of Narragansett, December 19, 1675.
Samuel Hills will, dated 5 August 1732, gave his property to his wife and seven of the nine sons who survived him. His sons Henry and James are not mentioned. In deeds dated 22 August 1721, Joseph gives with "the natural love and affection which I have and do bear unto my well beloved son, Henry Hills, and in full of his portion of my estate." As the consideration for the conveyance to him of "one-half part of all .. lands and meadow .... in the town of Dunstable, in the county of Middlesex ... on the easterly side of the Merrimack River ... which land and meadow was granted to my honored father, Mr. Joseph Hills, late of Newbury, deceased, and conveyed to me by the last will and testament of the said Joseph Hills ".