Married to Martin William Clayton around 1830.

Martin and Nancy were the parents of:
Martha Caroline Clayton Satterfield
Mary F Clayton Walters
Nancy Hargis Clayton O'Briant
Elizabeth Jane Clayton Long
James Henry Clayton
Lucy Ann Clayton Whitfield
William Martin Clayton
Minerva Isabella Clayton Walker
Cleopatra Clayton Fox
Samuel Clayton(1859-unk)
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Note 28 Nov 2020: Per member Lisa Oakley #49280171, Nancy's will lists a son, John D Clayton, probably emancipated before the 1850 US Census.
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1850 United States Federal Census
Name: Nancey Clayton
Age: 36
Estimated Birth Year: abt 1814
Birth Place: North Carolina
Gender: Female
Home in 1850: Person, North Carolina
Family Number: 300
Household Members: Name Age
Martin W Clayton 41
Nancey Clayton 36
Martha Clayton 18
Mary Clayton 15
Nancey Clayton 12
Jane Clayton 10
Henry Clayton 7
Lucy A Clayton 4
William Clayton 1

1860 United States Federal Census
Name: Nancy Clayton
Age in 1860: 45
Birth Year: abt 1815
Birthplace: North Carolina
Home in 1860: Person, North Carolina
Gender: Female
Post Office: Vanhooks Store
Household Members: Name Age
Martin Clayton 49
Nancy Clayton 45
Nancey Clayton 20
Jane Clayton 18
Henry Clayton 17
Lucy A Clayton 14
William Clayton 11
Manerva Clayton 7
Pittre Clayton 5
Samuel Clayton 1

1870 United States Federal Census
Name: Nancey H Clayton
Birth Year: abt 1813
Age in 1870: 57
Birthplace: North Carolina
Home in 1870: Roxboro, Person, North Carolina
Race: White
Gender: Female
Post Office: Roxboro
Household Members: Name Age
Martin Clayton 60
Nancey H Clayton 57
Lucey A Clayton 22
William N Clayton 19
Isabella Clayton 16
Clara P Clayton 11

1880 United States Federal Census
Name: Nancy Clayton
Home in 1880: Roxboro, Person, North Carolina
Age: 70
Estimated Birth Year: abt 1810
Birthplace: North Carolina
Relation to Head of Household: Wife
Spouse's Name: Marlin Clayton
Father's birthplace: North Carolina
Mother's birthplace: North Carolina
Occupation: Keeping House
Marital Status: Married
Race: White
Gender: Female
Household Members: Name Age
Marlin Clayton 73
Nancy Clayton 70
William Clayton 25
Belle Clayton 23
Petre Clayton 21
Wesly Wrenn 20