Luise was born the daughter of Frederick Wilhelm III, King of Prussia and his consort, Luise Augusta, Princess of Mecklenberg-Strelitz in Berlin, Brandenburg, Germany.
On 21 May 1825, she married Willem Frederick Karel, Prince of the Netherlands in Berlin.
They were the parents of 4 children-Wilhelmina Fredericke Alexandrine Anna (wife of King Karl XV of Sweden), Willem Frederick Nicholas Karel, Willem Frederick Nicholas Albrecht, and Wilhelmina Fredericke Alexandrine Anna Luise Maria.
Willem Frederik Karel Van Oranje-Nassau
1797–1881 (m. 1825)
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