Educated at Merchant Taylors School, and St.Johns College Oxford. He married Elizabeth, daughter of Louis Ourry of Blois (1682 - 1771), and his wife Ann Louise Beauvis at St.Matthew's, Bethnal Green, Dec.17, 1764.
The Rev. Samuel Beuzeville officiated as minister at "La Patente" from 1753 until 1761, and at the French Church of St Johns, Spitalfields for twenty four years from 1758 until his death, also at Fumes at the English Parish Church. His death is recorded in the Gentleman's Magazine 1782, page 46, under the heading of "Obituary of Considerable People".
In 1778 he was editor of Dr. David's "Vie d' Ostervald" and Agnew ,states that "the most valuable portion of this volume is the biographical preface by the Rev. Samuel Beuzeville, Pasteur of Bethnal Green"
Here lies near to his dear and venerable parents Samuel Beuzeville lately a humble minister of the French Church of St. John's in Spitalfields, born 16th April, 1717, died 3rd January 1782".