Through DNA comparison from the descendants of James Medcalf/Midkiff, I am a match to this James so much so to definitely be related. So thinking with those lines James very well could have been the unborn child of Thomas and Martha Medcalfe of New Castle County, Delaware Colony or a younger brother or a cousin to Thomas Medcalfe. This family came from the Medcalfe/Medcroft/Medcraft family of Oxfordshire, England which we are related to and not of the Metcalfe's of Yorkshire, England. We are not DNA related to those Metcalfe's in Yorkshire, England.
Closson, B., & Closson, M. (1991). Lancaster County, Pennsylvania, cemetery surname index. Apollo, PA: Closson Press.
"This book was compiled to help you determine if your ancestor(s) could be buried in Lancaster County, Pennsylvania. It provides the researcher access to almost all of the surnames found on tombstones in all listed cemeteries. It does NOT, however, include tombstone inscriptions" -- Letter.