She was the daughter of Catherine Rogers and James Ward.
She first married Israel R. Kirpatrick in New Rumley, Harrison County, Ohio, with whom she had two children
1). David Kirkpatrick (June 24, 1823- )
2). Lydia Ann Kirkpatrick
Israel Kirkpatrick died in 1835. She then married Emmanuel Henry Custer on February 23, 1836 at New Rumley, Ohio. Together they had seven children:
1). James Custer (1836-1837) Died in infancy
2). Samuel Custer (1838-1839) Died in infancy
3). George Armstrong Custer (December 5, 1839-June 25, 1876). Brevet Major General, US Army, Civil War. Lieutenant Colonel, 7th US Cavalry, died at the Battle of Little Big Horn.
4). Nevin Johnson Custer (July 29, 1842-February 25, 1915).
5). Thomas Ward Custer (March 15, 1845-June 25, 1876). Double Medal of Honor Recipient, Civil War. Captain, 7th US Cavalry, died at the Battle of Little Big Horn.
6). Boston Custer (October 31, 1848-June 25, 1876) Died at the Battle of Little Big Horn.
7). Margaret Emma Custer (January 5, 1852-1910). Married 1st Lieutenant James Calhoun, 7th US Cavalry. He died at the Battle of Little Big Horn.