Isaac was the son of George Williams and Nancy Newhouse, born in the Poor Valley near Brumley Creek, north of Abingdon, Washington Co, Virginia.

In 1810-11, Isaac's family crossed the Cumberland Gap from Virginia into Kentucky, then northward across Ohio river into Franklin County, Indiana Territory. About 1820, Isaac moved to Columbia Twp, Fayette, Indiana.

On 2 Oct 1828, Isaac married Rebecca Thompson in Fayette Co, Indiana, wed by his uncle, the Rev James Newhouse. Isaac and Rebecca moved their family from Indiana to Fulton Co, Illinois in 1839, and settled along Cedar Creek near Troy in Union Twp. Rebecca died in Jan 1865, and in March 1865, Isaac remarried Margaret Beck in Knox Co, Illinois.

*Fulton County Ledger, 04 June, 1885:
"Isaac Williams died at the residence of TA Baldwin, in Abingdon, May 20, 1885, aged 82 years. In 1839 he moved to Fulton County, and has resided in Illinois ever since." (*submitted by Judy Churchill; illinoisancestors.org)

Isaac is thought to be buried at Babbitt Cemetery in the middle of his family plot, next to his first wife Rebecca, and with his mother and children who died young. Isaac's second wife Margaret is also buried in Babbitt Cemetery.

Children of Isaac and Rebecca:
*Nancy Ann Williams, 1829 – 1912, m. Thomas Baldwin
*Susan J Williams, 1831 – 1841
*George Thomas Williams, 1833 – 1907, m. Lucinda Ogden
*Sarepta E Williams, 1836 – 1839
*Anson Luther Williams, 1839 – 1911, m. Margaret Mitchell
*Charles S Williams, 1841 – 1852
*Harriett Williams, 1844-1845
*John A Williams, 1847 – 1847
*Louis S Williams, 1850-1932, m. Lydia Ann Suydam
*Nora Williams, - 1852

Children of Isaac and Margaret:
*Martha Beck Williams, 1865 - bef 1920, m. John Meily
*Robert L Williams, 1866 – 1920, m. Harriet Swift
*Albert Grant Williams, 1869 – 1937, m. Irene Steel
*Frank Howard Williams, 1872 – aft 1940, m. Blanche Duke
*Pearl Mary Williams, 1878 – 1927, m. John Hainline