Friederike was born in Darmstadt the eldest daughter of Prince George William of Hesse-Darmstadt, second son of Louis VIII, Landgrave of Hesse-Darmstadt, and Countess Maria Luise Albertine of Leiningen-Dagsburg-Falkenburg. She married Duke Charles of Mecklenburg-Strelitz on September 18, 1768 in Darmstadt. They had ten children together. Two daughters became queens consort as Louise would marry Frederick William III of Prussia and Frederica would marry Ernest Augustus I of Hanover.
======================================================= ***Note*** She died two days after giving birth to her tenth child.