Fourth of eight children and second son of the Honorable Zattu Cushing 1771-1839 and his first wife, Rebecca Buckingham 1773-1816.

Husband of Abigail Browning Tupper, the daughter of Colonel Benjamin Tupper Jr and Martha Putman. They were married 25 Nov 1823 in Zanesville, Muskingum, Ohio and had the following children:
* Benjamin Tupper Cushing 1825-1850
* Edward Anselm Cushing 1827-1852
* Rowena Sophia Cushing, Mrs Asa Brown 1829-1858
* Abigail Elizabeth Cushing 1833-1834

Secondly, husband of Mary Barker Smith, the daughter of Elisha Smith and Mary Butler Bass and descendant of pilgrim John Alden. They were married 12 Jun 1836 in Baptist Church, Columbus, Franklin, Ohio and had the following children:
* Milton Buckingham Cushing 1837-1887
* Lt Howard Bass Cushing 1838-1871 killed by Apaches
* Walter Cushing 1839-1839
* Lt Col Alonzo Hereford Cushing 1841 - July 3, 1863
* Commander William Barker Cushing 1842-1874
* Mary Rachel Cushing 1845-1846
* Mary Isabel Cushing, Mrs Ed Gale & Mrs Eli Bouton 1847-1926

Milton Buckingham Cushing Dr graduated from Hamilton College, Utica, New York; also in the medical profession. Finding his practice too arduous, he embarked in a mercantile career, but resumed his practice again in Chicago, Illinois, before his death. He was for many years a merchant in Zanesville, Ohio. He also took a prominent part in educational matters, and was one of the pioneers in the anti-slavery and temperance movements.
In 1819 Milton entered Hamilton Literary and Theological Institute, a Baptist college in Hamilton, New York, which grew to become Madison College and eventually Colgate University. He wanted to become a doctor. But because he suffered from tuberculosis, a disease he may have contracted from his mother, he was unable to complete his schooling, although he often referred to himself in later life as "Dr. Cushing."
At his funeral a eulogist said "He was a man of elevated character, deep piety, acute and vigorous intellect. His influence was felt wherever he was known. As a business man he was energetic, persevering and clear-sighted. As a friend, he was constant, devoted and self-sacrificing. As a man he was full of benevolence and active charity. The poor found in him a ready benefactor and the oppressed a strong and unflinching advocate. He was a conscientious and active antislavery man and gave liberally of this money, and his time and thought, to assist in bringing freedom to the colored race. He was a handsome man of fine presence and was a society favorite. His death was deeply mourned by those whose affection his kindness had won and whose regard his sterling qualities had secured."

Milton was not robust [he had TB], "practiced" a few years in Ohio then moved to wilds of Wisconsin near Milwaukee with Milton Jr and children from first marriage. Family histories all cite him as physician, but Hamilton College was only open 1 year before he moved to Ohio. No record there of his graduation. He was probably was store keeper in Ohio and fairly certainly not a physician.
1839 they went to log cabin few miles north of Waukesh Wisconsin, halfway between Lakes Nemahbin and Nagawick, no. of Bark R., now village of Delafield. By 1844 the outdoor existence was too strenuous -- moved to Chicago Illinois. He lived on the waterfront. By 1846 he was worse, decided to travel to visit cousin Judge L. S. Houghton of Vicksburg, Michigan. Then he removed to Columbus Ohio; then in Galllipolis, Ohio his cold went to pneumonia in hotel bedroom. Wife (Mary Barker) accompanied the body to Fredonia where he was buried.
He was a pioneer in anti-slavery and temperence movements.