The Basilica of Santa Maria del Santo Spirito ("St. Mary of the Holy Spirit") is a church in Florence, Italy. Usually referred to simply as Santo Spirito, it is located in the Oltrarno quarter, facing the square with the same name. The building on the interior is one of the pre-eminent examples of Renaissance architecture.

The current church was constructed over the pre-existing ruins of an Augustinian priory from the 13th century, destroyed by a fire. Filippo Brunelleschi began designs for the new building as early as 1428. After his death in 1446, the works were carried on by his followers Antonio Manetti, Giovanni da Gaiole, and Salvi d'Andrea; the latter was also responsible for the construction of the cupola.

The Basilica of Santa Maria del Santo Spirito ("St. Mary of the Holy Spirit") is a church in Florence, Italy. Usually referred to simply as Santo Spirito, it is located in the Oltrarno quarter, facing the square with the same name. The building on the interior is one of the pre-eminent examples of Renaissance architecture.

The current church was constructed over the pre-existing ruins of an Augustinian priory from the 13th century, destroyed by a fire. Filippo Brunelleschi began designs for the new building as early as 1428. After his death in 1446, the works were carried on by his followers Antonio Manetti, Giovanni da Gaiole, and Salvi d'Andrea; the latter was also responsible for the construction of the cupola.