Although earlier cemeteries which have since disappeared existed at Monroe and Front Streets and Monroe at 6th Street, this sacred ground is the successor to the first parish cemetery established in 1794 and abandoned in 1830. That first cemetery was located west of Monroe on N. Custer Rd. as part of the St. Antoine's church land. Parishioners renamed their church St. Mary's, locating it at Elm Avenue and Monroe Street and consecrating a new burial ground on this site.

During the cholera epidemic of 1832 victims of all nationalities and religions were buried alongside the Roman Catholic parishioners to whom it was once dedicated.

Although earlier cemeteries which have since disappeared existed at Monroe and Front Streets and Monroe at 6th Street, this sacred ground is the successor to the first parish cemetery established in 1794 and abandoned in 1830. That first cemetery was located west of Monroe on N. Custer Rd. as part of the St. Antoine's church land. Parishioners renamed their church St. Mary's, locating it at Elm Avenue and Monroe Street and consecrating a new burial ground on this site.

During the cholera epidemic of 1832 victims of all nationalities and religions were buried alongside the Roman Catholic parishioners to whom it was once dedicated.