Son of William Cain and Mary Ruffin Cain.

Married to Elizabeth Julia A Tate around 1855.

James and Julia were the parents of:
Mary Ruffin Cain Trezevant
James Frederick Cain
Elizabeth Tate Cain Hinton
Sterling William Cain
Julia Tate Cain Manning
Annie Preston Cain Bridgers
Susan Marshall Cain Green
Samuel Robert Cain

James had a long term relationship with Annie Weaver.

James and Annie were the parents of:
Lula Weaver Cain Banks
Octavius Calvin Cain
Nellie Weaver Locklear
**********************************
1850 United States Federal Census
Name: James Cain
Age: 21
Estimated birth year: abt 1829
Birth Place: North Carolina
Gender: Male
Home in 1850 (City,County,State): District 1, Orange, North Carolina
Family Number: 1376
Household Members: Name Age
Mary White 60
James Cain 21

1860 United States Federal Census
Name: James F Cain
Age in 1860: 30
Birth Year: abt 1830
Home in 1860: Orange, North Carolina
Gender: Male
Household Members: Name Age
James F Cain 30
Julia Cain 25
Mary Cain 4
James Cain 2
Elizabeth Cain 4/12

U.S. Civil War Soldier Records and Profiles
Name: James Frederick Cain
Residence: Orange County, North Carolina
Age at Enlistment: 33
Enlistment Date: 3 Nov 1862
Rank at enlistment: 1st Lieut
Enlistment Place: Orange County, NC
State Served: North Carolina
Survived the War?: Yes
Service Record: Commissioned an officer in .
Promoted to Full 1st Lieutenant on 15 Mar 1862.
Commissioned an officer in Company G, North Carolina Co. G 3rd Light Artillery Battery on 11 Mar 1862.
Mustered out on 10 Dec 1862.
Promoted to Full Assist Surg.
Promoted to Full Surg.
Birth Date: abt 1829
Sources: North Carolina Troops 1861-65, A Roster

1870 United States Federal Census
Name: James F Cain
Birth Year: abt 1829
Age in 1870: 41
Birthplace: North Carolina
Home in 1870: Little River, Orange, North Carolina
Race: White
Gender: Male
Household Members: Name Age
James F Cain 41
Julia Cain 36
Mary Cain 14
Janes Cain 12
Bessie Cain 10
Sterling Cain 8
Julia Cain 6
Susan Cain 4
Annie Cain 5
Maria Hill 13 (white female)
Dempsey Hill 45 (black male)
Milley Page 45 (black female)

1880 United States Federal Census
Name: James F Cain
Home in 1880: Little River, Orange, North Carolina
Age: 50
Estimated birth year: abt 1830
Birthplace: North Carolina
Relation to Head of Household: Self (Head)
Spouse's name: Julia E.
Father's birthplace: North Carolina
Mother's birthplace: North Carolina
Occupation: Farmer Physician
Marital Status: Married
Race: White
Gender: Male
Household Members: Name Age
James F Cain 50
Julia E Cain 48
Maimie Cain 24
James F Cain 22
Bessie T Cain 19
Sterling W Cain 18
Julia T Cain 16
Susan N Cain 13
Anna P Cain 11
Saml R Cain 9

1900 United States Federal Census
Name: James F Cain
Home in 1900: Lebanon, Durham, North Carolina
Age: 71
Birth Date: Sep 1828
Birthplace: North Carolina
Race: White
Gender: Male
Relationship to Head of House: Head
Father's Birthplace: North Carolina
Mother's Birthplace: North Carolina
Spouse's name: Julia E
Marriage Year: 1855
Marital Status: Married
Years Married: 45
Household Members: Name Age
James F Cain 71
Julia E Cain 68