He was the son of Jacob Huffer and Susannah W. Caricofe. He married Jane McQuaine.
Obituary from the Staunton newspaper:
Mt. Solon News.
Mt. Solon, April 21, '90. Mr. Samuel Huffer, who lived on North River, near here, died, aged about sixty years. He leaves a devoted wife and one child. His death has cast a gloom over the community where he lived. He was one of the few men who attended to his business and let other people's business alone; honest and upright in all his dealings, and a christian in whom there was no hypocricy.