Isme was the fifth child out of nine born to Michael Freeman and Elizabeth Duncan. He was a farmer. He married Susannah Oppy (a daughter of David Oppy and Elizabeth Edwards). They were wed on October 5, 1820 in Blue Creek Adams County), Ohio. They had twelve children; seven sons and five daughters. After Susannah's death in 1849, Isme married a woman named Martha and they had two children.