Mary A Challender was the daughter of Daniel B Challender and Joanna L Danser Challender who are buried in Jacobstown Baptist Cemetery. Her brothers Elmer, John, and Benjamin Challender as well as a sister Bertha Challender Davis are also buried in Jacobstown Baptist Cemetery. Her brother Edward F Challender is buried in the Jacobstown Schoolhouse Road Cemetery. Her younger sister Laura Shumard is also buried somewhere in the area, and her oldest sister's whereabouts are unknown.
Mary Challender married John Murphy Burke and they had five daughters: Anna Barry, Etta Welsh, Ethel Glackin, Ceola Burke, and Winnie Poinsett.