Isabelle Melissa Thompson was born in Wilcox County, Alabama, daughter of Elizabeth and Richard N. Thompson. She married, John Hugh Arledge on January 5, 1859 in Pineapple, Alabama. They later moved to Rockdale, Milam County, Texas. They had eight children. John Hugh joined the Confederate Army and served in the Red River Campaign. Isabelle was active in the United Daughters of the Confederacy after John Hugh died. She died in Rockdale July 19, 1913.