Jonathan Columbus Loftin was the son of Gray Gene Loftin and Priscilla Badgett Loftin. He was the twin brother of Daniel Rufus Loftin. He was the husband of Frances Smith (married in Davidson County October 19, 1871). He was the father of Rev. Albert Gray Loftin, Lillie G. Loftin and George Cornelius (Neal) Loftin.