S. Crain was born to Edward Crain and Elizabeth C. Dial. She had four half siblings, Matilda, Emily Marcus O. (deceased), Laura and Lucy. Her full siblings at the time of her birth were William Porter and sister Florence E. Crain that had died in 1859, the year before her birth. Sister Carrie Belle was born in 1864.
Where her parents were living at the time she died is unknown as they moved about then. S. Crain was shown in the 1860 US. census and shown as 4 mo. old at that time.