Son of Thomas Ruffin and Anne McNabb Kirkland Ruffin.

Married to Sarah Elizabeth Tayloe around 1856.

John and Sarah were the parents of:
Katharine Ruffin Sydnor
Sarah A Ruffin
Anne Cameron Ruffin Sims
David Tayloe Ruffin
Dr Sterling Ruffin
Mary Ruffin
Thomas Ruffin
Dr George Mendenhall Ruffin

Married to Penninah Watson Ruffin on March 3, 1886 in Franklin County, North Carolina.
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1850 United States Federal Census
Name: Jno K Ruffin
Age: 16
Birth Year: abt 1834
Birthplace: North Carolina
Home in 1850: South District, Alamance, North Carolina
Gender: Male
Family Number: 39
Household Members:
Name Age
Thos Ruffin 62
An M Ruffin 56
Mary M Bryant 50
Wm K Ruffin 38
Allice Ruffin 34
Sterling Ruffin 32
Jane Ruffin 20
Martha Ruffin 18
Jno K Ruffin 16
Sally N Ruffin 14
Samuel Patton 40
Margaret Patton 39
John Patton 2
Mary Patton 0

1860 United States Federal Census
Name: Jno K Ruffin
Age: 26
Birth Year: abt 1834
Gender: Male
Race: White
Home in 1860: Washington, Beaufort, North Carolina
Family Number: 1629
Household Members:
Name Age
Jno K Ruffin 26
Sally Ruffin 22
Kate Ruffin 2
Sally Ruffin 4/12
J W Woolen 26

1870 United States Federal Census
Name: Jno K Ruffin
Age in 1870: 36
Birth Year: abt 1834
Birthplace: North Carolina
Home in 1870: Graham, Alamance, North Carolina
Race: White
Gender: Male
Post Office: Graham
Household Members:
Name Age
Jno K Ruffin 36
Sarah Ruffin 32
Catharine Ruffin 12
Sallie Ruffin 10
Annie Ruffin 8
David Ruffin 6
Sterling Ruffin 3

1880 United States Federal Census
Name: John K. Ruffins
Age: 46
Birth Year: abt 1834
Birthplace: North Carolina
Home in 1880: Wilson, Wilson, North Carolina
Race: White
Gender: Male
Relation to Head of House: Self (Head)
Marital Status: Married
Spouse's Name: Sallie E. Ruffins
Father's Birthplace: North Carolina
Mother's Birthplace: North Carolina
Occupation: Physician
Household Members:
Name Age
John K. Ruffins 46
Sallie E. Ruffins 42
Kate R. Ruffins 21
Sallie A. Ruffins 20
Annie C. Ruffins 18
David T. Ruffins 16
Sterling Ruffins 13
Mary Ruffins 9
Thomas Ruffins 7
George M. Ruffins 3

North Carolina, Marriage Records, 1741-2011
Name: John K Ruffin
Gender: Male
Race: White
Age: 52
Birth Year: abt 1834
Marriage Date: 3 Mar 1886
Marriage Place: Franklin, North Carolina
Spouse: Ninie W Ruffin
Spouse Gender: Female
Spouse Race: White
Spouse Age: 50
Spouse Father: Hop G Ruffin
Spouse Mother: Mary T Ruffin
Event Type: Marriage