Born at Spring Creek, Washington County, Virginia. She is a lineal descendant of John Knox, the Reformer. She moved to Texas with her parents in 1874 and lived at Burnett and Georgetown, Texas. Her father was a Presbyterian minister who came to Texas from Virginia. She attended Southwestern University from 1886-1888.
Joseph Akin married Margaret Rose on 1 January 1900 at Burnett, Texas. There were seven children born to this union: three sons and four daughters. The couple moved to Wichita Falls in 1915.
In later life, Margaret Rose Akin wrote poetry, of which a major portion was published.
Margaret Akin was living at University Park in Dallas, Texas at the time of her death.
"Life's Afterglow" was her first book of poetry published by William T. Tardy, Dallas, Texas. The title poem, "In Life's Afterglow" reads:
My youth is past, with all its dreams And middle age of sacred years; But now surprising glory streams - Life's rosy afterglow appears:
I think its kinder light's advance Will fall on silver hair and rest In haloes that the years enhance - Life's afterglow should be the best.