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Dr Israel Herbert Scheinberg

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Dr Israel Herbert Scheinberg

Birth
Manhattan, New York County, New York, USA
Death
4 Apr 2009 (aged 89)
Elizabethtown, Essex County, New York, USA
Burial
Burial Details Unknown Add to Map
Memorial ID
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Physician and Scientist. During the 1950s he discovered a safe, inexpensive test and treatment for Wilson's Disease, a rare, and previously 100% fatal, autosomal recessive genetic liver disorder. Raised in New York City, he was valedictorian of his class at De Witt Clinton High School in the Bronx in 1936. He earned a degree in chemistry from Harvard in 1940, and his M.D. from the same institution in 1943. After internship at Peter Bent Brigham Hospital, in Boston, he served in the Army Medical Corps during WWII, then returned to Harvard on a fellowship. Dr. Scheinberg was a founding professor of internal medicine at Albert Einstein College of Medicine, in the Bronx, from 1955 until he took emeritus status in 1992. In the 1950s, he studied Wilson's Disease, a hereditary deficiency of ceruloplasmin leading to abnormal deposition of dietary copper in the liver, brain, kidneys, and heart, first described by Dr. Samuel A.K. Wilson in 1912. The condition often presents initially with psychiatric manifestations (fulminant hepatic failure is the presentation only 5% of the time), and thus is difficult to diagnose in the early stages. Dr. Scheinberg developed a test for serum ceruloplasmin still in use today (along with liver biopsy, and examination for the pathonomonic sign of the condition, the Kayser-Fleischer ring, a reddish-brown accumulation of copper in Descemet's membrane of the cornea, easily visible under a slit-lamp). At the same time, he began treating the disease with D-penicillamine, which promotes excretion of copper in the urine. This remains the basis of treatment, along with administration of zinc, and the avoidance of sources of dietary copper, such as organ meats, shellfish, chocolate, and nuts. The prognosis changed from that of rapid painful death to living a normal life. In his later years, Dr. Scheinberg did research into Menke's Disease, a very rare sort-of "mirror image" of Wilson's in which patients are unable to retain the small amounts of copper necessary for life. He remained a noted long-distance runner into his 80s, winning several trophies in his age-group, and died in a New Jersey nursing home after a long illness.
Physician and Scientist. During the 1950s he discovered a safe, inexpensive test and treatment for Wilson's Disease, a rare, and previously 100% fatal, autosomal recessive genetic liver disorder. Raised in New York City, he was valedictorian of his class at De Witt Clinton High School in the Bronx in 1936. He earned a degree in chemistry from Harvard in 1940, and his M.D. from the same institution in 1943. After internship at Peter Bent Brigham Hospital, in Boston, he served in the Army Medical Corps during WWII, then returned to Harvard on a fellowship. Dr. Scheinberg was a founding professor of internal medicine at Albert Einstein College of Medicine, in the Bronx, from 1955 until he took emeritus status in 1992. In the 1950s, he studied Wilson's Disease, a hereditary deficiency of ceruloplasmin leading to abnormal deposition of dietary copper in the liver, brain, kidneys, and heart, first described by Dr. Samuel A.K. Wilson in 1912. The condition often presents initially with psychiatric manifestations (fulminant hepatic failure is the presentation only 5% of the time), and thus is difficult to diagnose in the early stages. Dr. Scheinberg developed a test for serum ceruloplasmin still in use today (along with liver biopsy, and examination for the pathonomonic sign of the condition, the Kayser-Fleischer ring, a reddish-brown accumulation of copper in Descemet's membrane of the cornea, easily visible under a slit-lamp). At the same time, he began treating the disease with D-penicillamine, which promotes excretion of copper in the urine. This remains the basis of treatment, along with administration of zinc, and the avoidance of sources of dietary copper, such as organ meats, shellfish, chocolate, and nuts. The prognosis changed from that of rapid painful death to living a normal life. In his later years, Dr. Scheinberg did research into Menke's Disease, a very rare sort-of "mirror image" of Wilson's in which patients are unable to retain the small amounts of copper necessary for life. He remained a noted long-distance runner into his 80s, winning several trophies in his age-group, and died in a New Jersey nursing home after a long illness.

Bio by: Bob Hufford


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