Saint Andrew's Cemetery is located at 299 Queen Street South, adjacent to St. Andrews Presbyterian Church, on the west side of the Credit River and in the village of Streetsville.

Before the erection of the Presbyterian church next to the cemetery, there was no prayer or service and the early Presbyterian burials of Streetsville were held within the confines of a forest. Timothy Street, an Anglican, after whom Streetsville is named, wished this burial situation to be remedied. On February 24, 1824 he gave the Presbyterians a portion of his land for a burying ground to be used for all Protestant denominations. For years this cemetery remained the only Protestant burying ground for a large district, with individuals from Churchville and Brampton having to come here for burial. Few Anglicans were buried here after the founding of the Anglican Cemetery.

In 1824, the Presbyterian congregation made preparations to erect a church. The first preserved records began with Reverend W. Rintoul. According to the 1856 official map of Streetsville, the Cemetery was known as the Scotch Burying Ground. On November 1, 1868, the brick church that still stands today was opened. In 1890, the Council closed the Cemetery and the last burial occurred in 1895. Streetsville's dead were to be buried in Streetsville Public Cemetery on the East side of the Credit River. It is believed that some individuals buried in this cemetery were moved by their families in the early twentieth century into new family plots in Streetsville Public cemetery.

On June 28, 1959, a new stone was erected and the cemetery was dedicated as Memorial Cemetery. Today, the cemetery is maintained by the City of Mississauga. According to records, there are approximately 500 burials in the cemetery, 22 being without stones. The remaining stones within the cemetery account for 293 of these burials.